Prof. Gian Maria Pacifici

LIST OF PUBLICATIONS (Papers only)

    • E. Di SALLE, G.M. PACIFICI and P.L. MORSELLI: Studies on plasma protein binding of carbamazepine. Pharmacol. Res. Commun. 6, 193-202 (1974).
    • E. Di SALLE, G.M. PACIFICI and P.L. MORSELLI: Studies on plasma protein binding of carbamazepine. Pharmacol. Res. Commun. 6, 193-202 (1974).
    • P.L. MORSELLI, M. NARDINI, G.M. PACIFICI, F. SORGONA, R. LATINI, P. FERRARI and C. FIESCHI: Farmacocinietica dell’amantadina nel volontario e nelle sindromi extrapiramidali da neurolettici. Correlazioni tra livelli plasmatici ed effetti. In: Stato attuale delle conoscenze sulle malattie extrapiramidali, (A. Agnoli and G. Bertolani, eds) pp. 186-204, L’Aquila (1974).
    • G. F. PLACIDI, G. TOGNONI, G.M. PACIFICI, G.B. CASSANO and P.L. MORSELLI: Regional distribution of diazepam and its metabolites in the brain of cat after chronic treatment. Psychopharmacol. 48,133-137 (1976).
    • G.M. PACIFICI, M. NARDINI, P. FERRARI, R. LATINI, C. FIESCHI, and P.L. MORSELLI: Effect of amantadine on drug-induced parkinsonism: relationship between plasma levels and effect. Br. J. Clin. Pharmacol. 3, 883-889 (1976).
    • G.M. PACIFICI, P. FORNARO, M. GUARNERI nad G.F. PLACIDI: Farmacocinetica di alcuni derivati benzodiazepinici: confronto fra soggetti giovani ed anziani. In: Il sonno nell’eta’ senile. pp 175-182 (A. Muratorio, C. Maggini, L. Murri eds) Pacini Editore, Pisa (1976).
    • G.F. PLACIDI, G.M. PACIFICI, M. GUARNERI, P. FORNARO, G. MOGGI, G. ARCIDIACONO and N. CAPPELLI: Distribuzione fetale di farmaci psicotropi livelli ematici e passaggio feto-trasplacentare di derivati benzodiazepinici. Simposio della Societa’ Italiana di Neurofarmacologia. pp 1-13 Anacapri (1976).
    • G.M. PACIFICI, G. BIANCHETTI, A. FRIGERIO, R. GOMENI, P.L. MORSELLI, S. GARATTINI, G. PIFFERI and C. CARPI: Pharmacokinetics and biotraformation, in rats and dogs, of trithiozine, a new antisecretory drug. Eur. J. Drug Metab. Pharmacokinet. 1, 141-147 (1976).
    • G.M. PACIFICI and G.F. PLACIDI: Rapid and sensitive electron-capture gaschromatographic method for the determination of pinazepam and its metabolites in human plasma, urine and milk. J. Chromatogr. 135,133-139 (1977).
    • G.M. PACIFICI, C. PELLEGRINO, C. MAFFEI and D. BECONCINI: Effect of denervation on the enzymes regulating cyclic AMP in the rat gastrocnemius muscle. In: Molecular Biology and Pharmacology of Cyclic Nucleotides (G. Folco, R. Paoletti eds) pp 297-300. Elsevier/North-Holland Biochemical Press (1978).
    • G.M. PACIFICI, A.R. BOOBIS, M.J. BRODIE and D.S. DAVIES: A rapid sensitive assay for glutathione S-epoxidetransferase activity: species differences in the activity of the hepatic enzyme. Biochem. Soc. Trans. 7, 1060-1061 (1979).
    • A. R. BOOBIS, D.S. DAVIES and G.M. PACIFICI: Developmental changes in the inducibility of drug metabolising enzymes by 3-methylcholanthrene in hepatic and extrahepatic tissues of the rabbit. Br. J. Pharmacol. 69, 321P-322P (1979).
    • M.E. MCMANUS, A.R. BOOBIS, G.M. PACIFICI, R.Y. FREMPONG, M.J. BRODIE, G.C. KAHN, C. WHYTE and D.S. DAVIES: Xenobiotic metabolism in the human lung. Life Sci. 26, 481-487 (1980).
    • A. RANE and G.M. PACIFICI: Formation and metabolism of toxic metabolites in the human fetus. In: Drug Metabolism in the Immature Human (L.F. Soyka and G.P. Redmond) pp. 29-35. Raven Press, New York (1981).
    • G.M. PACIFICI, A.R. BOOBIS, M.J. BRODIE, M.E. MACMANUS and D.S. DAVIES: Tissue and species differences in enzymes of epoxide metaboism. Xenobiotica 11, 73-79 (1981).
    • G.M. PACIFICI, J. SAWE, L. KAGER and A. RANE: Morphine glucuronidation in human fetal and adult liver. Eur. J. Clin. Pharmacol. 22, 553-558 (1982).
    • G.M. PACIFICI, C. PELLEGRINO, C. MAFFEI and D. BENCINI: Effect of denervation on cyclic AMP regulating enzymes in the rat gastrocnemius muscle. Ital. J. Biochem. 30, 20-29 (1981).
    • G.M. PACIFICI and A. RANE: Intestinal and hepatic morphine glucuronidation in immature and pregnant rats. Dev. Pharmacol. Ther. 3,160-167 (1981).
    • G.M. PACIFICI, L. CUOCI, G.F. PLACIDI, P. FORNARO and R. GOMENI: Elimination kinetics of desmethyldiazepam in two young and two elderly subjects. Eur. J. Drug Metab. Pharmacokinet. 7, 69-72 (1982).
    • G.M. PACIFICI and G.F. PLACIDI: First pass effect of pinazepam in the rat liver. Eur. J. Drug Metab. Pharmacokinet. 7, 119-122 (1982).
    • G.M. PACIFICI and A. RANE: Glutathione S-epoxidetransferase in the human placenta at different stages of pregnancy. Drug Metab. Disp. 9, 472-475 (1981).
    • G.M. PACIFICI, A. NORLIN and A. RANE: Glutathione S-transferase in human fetal liver. Biochem. Pharmacol. 30, 3367-3371 (1981).
    • M. WARHOLM, C. GUTHENBERG, B. MANNERVIK, G.M. PACIFICI and A. RANE: Glutathione S-transferases in human fetal liver. Acta Chem. Scand. B35, 225-227 (1981).
    • G.M. PACIFICI, G.F. PLACIDI, P. FORNARO and R. GOMENI: Pinazepam: a precursor of N-desmethyldiazepam. Eur. J. Clin. Pharmacol. 22, 225-228 (1982).
    • G.M. PACIFICI and A. RANE: Distribution of UDP-glucuronyltransferase in different human fetal tissues. Br. J. Clin. Pharmacol.13, 732-735 (1982).
    • G.M. PACIFICI, L. CUOCI, G.F. PLACIDI: Disposition, distribution, plasma protein binding and biliary excretion of pinazepam after i.p. administration to rat. Eur. J. Drug Metab. Pharmacokinet. 8, 209-217 (1983).
    • G.M. PACIFICI, L. CUOCI and G.F. PLACIDI: Disposition, distribution, and liver first-pass effect of pinazepam in the rat. Drug Metab. Disp.10, 180-182 (1982).
    • J. SAWE, G.M. PACIFICI, L. KAGER, C. von Bahr and A. RANE: Glucuronidation of morphine in human liver and interaction with oxazepam. Acta Anaesth. Scand. Suppl. 74, 47-51 (1982).
    • G.M. PACIFICI and A. RANE: Inhibition of morphine glucuronidation by oxazepam in human fetal liver microsomes. Drug Metab. Disp. 9, 569-572 (1981).
    • G.M. PACIFICI and A. RANE: Metabolism of styrene oxide in different human fetal tissues. Drug Metab. Disp.10, 302-305 (1982).
    • G.M. PACIFICI, G.F. PLACIDI, P. FORNARO and R. GOMENI: Pharmacokinetics of pinazepam in healthy volunteers. Int. J. Clin. Pharmacol. Res. 3, 331-337 (1983).
    • G.M. PACIFICI and A. RANE: Renal glucuronidation of morphine in human foetus. Acta Pharmacol. Toxicol. 50,155-160 (1982).
    • G.M. PACIFICI and A. RANE: Epoxide hydrolase in human fetal liver. Pharmacology 26, 241-248 (1983).
    • G.M. PACIFICI and A. RANE: Epoxide hydrolase in human placenta at different stages of pregnancy. Dev. Pharmacol. Ther. 6, 83-93 (1983).
    • G.M. PACIFICI, C. COLIZZI, L. GIULIANI and A. RANE: Nuclear epoxide hydrolase in the human fetal and adult liver. Pharmacology 28, 321-328 (1984).
    • G.M. PACIFICI, D.S. DAVIES, C. WHYTE and A.R. BOOBIS: Tissue differences in the ontogeny of inducibility of drug-metabolizing enzymes by 3-methylcholanthrene in the rabbit. Xenobiotica 12, 591-598 (1982).
    • G.M. PACIFICI, B. LINDBERG, H. GLAUMANN and A. RANE: Styrene oxide metabolism in rhesus monkey liver: enzyme activities in subcellular fractions and isolated hepatocytes. J. Pharmacol. Exper. Ther. 226, 869-975 (1983).
    • G.M. PACIFICI C. COLIZZI, L. GIULIANI and A. RANE: Cytosolic epoxide hydrolase in fetal and adult human liver. Arch. Toxicol. 54, 331-341 (1983).
    • G.M. PACIFICI, G. TADDEUCCI-BRUNELLI and A. RANE: Clonazepam serum protein binding during development. Clin. Pharmacol. Ther. 35, 354-359 (1984).
    • G.M. PACIFICI and A. RANE: Profile of drug metabolizing enzymes in the nuclei and microsomes of hepatic and extrahepatic tissues from monkeys. In: Extrahepatic Drug Metabolism and Chemical Carcinogenesis (J. Rydstrom, J. Montelius, M. Bengtsson, eds) pp 33-37 (1983).
    • D.R. PENG, G.M. PACIFICI and A. RANE: Human fetal liver cultures: basal activities and inducibility of epoxide hydrolase and aryl hydrocarbon hydroxylase. Biochem. Pharmacol. 33, 71-77 (1984).
    • G.M. PACIFICI, D. PENG and A. RANE: Epoxide hydrolase and aryl hydrocarbon hydroxylase in human fetal tissues: activities in nuclear and microsomal fractions and isolated hepatocytes. Ped. Pharmacol. 3, 189-197 (1983).
    • G.M. PACIFICI: Epoxide detoxification pathways in human fetus. Academic thesis for Ph. D. in Medical Sciences, The Karolinska Institute, Huddinge Hospital, Stockholm (1983).
    • D.R. PENG, G.M. PACIFICI and A. RANE: Induction of drug metabolism in human fetal cultures. In: Drugs and Pregnancy (B. Krauer, F.E. Hytten, E. del Pozo, eds) pp. 73-83 (1984).
    • G.M. PACIFICI, L. CUOCI and A. RANE: Subcellular distribution of styrene oxide in rat liver. Toxicol. Pathol.12, 69-73 (1984).
    • G.M. PACIFICI, H. GLAUMANN ana A. RANE: Isolation of nuclear fractions from human fetal tissues. Ultrastructure and presence of epoxide hydrolase and aryl hydrocarbon hydroxylase. Pharmacology 30, 188-196 (1985).
    • G.M. PACIFICI, L. CUOCI and G.F. PLACIDI: Subcellular distribution of pinazepam and its metabolite N-desmethyldiazepam in rat liver. Gen. Pharmacol. 15, 353-355 (1984).
    • G.M. PACIFICI, M. WARHOLM, C. GUTHENBERG, B. MANNERVIK and A. RANE: Organ distribution of glutathione transferase isoenzymes in the human fetus: differences between liver and extrahepatic tissues. Biochem. Pharmacol. 35, 1616-1619 (1986).
    • G.M. PACIFICI, C. GUTHENBERG, M. WARHOLM, B. MANNERVIK and A. RANE: Conjugation of styrene oxide by the basic and acidic forms of glutathione transferase in the human fetal liver. Dev. Pharmacol. Ther. 11, 243-251 (1988).
    • G.M. PACIFICI, L. CUOCI, M. GUARNERI, P. FORNARO, G. ARCIDIACONO, G. MOGGI and G.F. PLACIDI: Placental transfer of pinazepam and its metabolite N-desmethyldiazepam in women at term. Eur. J. Clin. Pharmacol. 27, 307-310 (1984).
    • A. RANE, J. SAWE, G.M. PACIFICI, J.O. SVENSSON and L. KARGER: Regioselective glucuronidation of morphine and interactions with benzodiazepines in humans. In: Advances in Pain Research (K.M. Foley, C.E. Inturrisi, eds) pp 57-64. Raven Press (1986).
    • G.M. PACIFICI, C. COLIZZI, L. GIULIANI and A. RANE: Nuclear and microsomial UDP-glucuronyltransferase in human liver. In: Advances in Glucuronide Conjugation (S. Matern, K.W., Bock and W. Gerok, eds) pp 341-350 MTP Press Limited, Lancaster (1985).
    • G.M. PACIFICI, A. VIANI, G. RIZZO, M. CARRAI and A. RANE: Plasma protein binding of clonazepam in hepatic and renal insufficiency and after haemodialysis. Ther. Drug Monitor. 9, 87-91 (1986).
    • G.M. PACIFICI, C. BENCINI and A. RANE: Presystemic glucuronidation of morphine in humans and rhesus monkeys: subcellular distribution of the UDP-glucuronyltransferase in the liver and intestine. Xenobiotica 16, 123-128 (1986).

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