Prof. Gian Maria Pacifici

  • G.M. PACIFICI, M.A. FERRONI, A. TEMELLINI, A. GUCCI, M.C. MORELLI and L. GIULIANI: Human liver budesonide sulphotransferase is inhibited by testosterone and correlates with testosterone sulphotransferase, Eur. J. Clin. Pharmacol. 46, 49-54 (1994).
  • G.M. PACIFICI, A. TEMELLINI, A. VIANI, P. ROMITI, R. BIGOTTI, P. DONATELLI, M. CASTIGLIONI and L. GIULIANI: Conjugation pathways in human liver: a study on the interindividual variability. In: Mechanisms of Toxicity and Their Relevance in Industrial Toxicology. (M. Lotti and M. Manno, eds) pp 65-72 (1993). SGEditoriali, Padova. (ISBN 88-86281-00-5).
  • P. DONATELLI, G. MARCHI, L. GIULIANI, L. GUSTAFSSON and G.M. PACIFICI: Stereochemical inhibition of histamine N-methyltransferase by chloroquine. Eur. J. Clin. Pharmacol. 47, 345-349 (1994).
  • G.M. PACIFICI and R. NOTTOLI: Placental transfer of drugs administered to the mother. Clin. Pharmacokinet. 28, 235-269 (1995).
  • G.M. PACIFICI, TEMELLINI, M. CASTIGLIONI, C. D’ALESSANDRIA, A. GUCCI and L. GIULIANI: Interindividual variability of the human liver hepatic sulphotransferases. Chem.-Biol. Interact. 92, 219-231 (1994).
  • A. TEMELLINI, M. CASTIGLIONI, L. GIULIANI, A. MUSSI, P.C. GIULIANOTTI, A. PIETRABISSA, C.A. ANGELETTI, F. MOSCA and G.M. PACIFICI. Glutathione conjugation with 1-chloro-2,4-nitrobenzene: interindividual variability in human liver, lung, kidney and intestine. Int. J. Clin. Pharmacol. Ther. 33, 498 – 503 (1995).
  • G.M. PACIFICI and C. DE SANTI: Human sulphotransferase. Classification and metabolic profile of the major isoforms. The point of view of the clinical pharmacologist. In: Advances in Drug Metabolism in man (G.M. Pacifici and G.N. Fracchia, eds) pp 311-349 (1995). European Commission, Luxembourg/Brussels. (EUR 15439 – ISBN 92-827-3982-1)
  • G.M. PACIFICI and G.N. FRACCHIA: Human methyltransferases. Classification and metabolic profile of the major isoforms. The point of view of the clinical pharmacologist. In: Advances in Drug Metabolism in man (G.M. Pacifici and G.N. Fracchia, eds), pp 461- 493 (1995). European Commission, Luxembourg/Brussels. (EUR 15439 – ISBN 92-827-3982-1)
  • G.M. PACIFICI, C. DE SANTI, A. MUSSI and C.A. ANGELETTI: Interindividual variability in the rate of salbutamol sulfation in the human lung. Eur. J. Clin. Pharmacol. 49, 299-303 (1996).
  • M.A. FERRONI, G. MARCHI, E. SANSONE, P. ROMEO, P.C. GIULIANOTTI, A. PIETRABISSA, F. MOSCA and G.M. PACIFICI: Variability in the rate of 6-mercaptopurine methylation in the erythrocytes, liver and kidney of an Italian population. Eur. J. Clin. Pharmacol. 51, 23-26 (1996).
  • G.M. PACIFICI, L. EVANGELISTI and L. GIULIANI: Zidovudine glucuronosyl transferase in human liver: interindividual variability. Int. J. clin. Pharmacol. Ther. 34, 329-334 (1996).
  • G.M. PACIFICI: Drug transport across human placenta: Theoretical and methodological approach. In: European Medicines Research. Perspectives in Clinical Trials (G.N. Fracchia, Ed) PP 125-135 (1995). The Commission of the European Commission, Belgium, Brussels. (ISBN 0 9526643 0 5).
  • G.M. PACIFICI, B. GIULIANETTI, M.C. QUILICI, R. SPISNI, M. NERVI, L. GIULIANI and R. GOMENI: (-)-Salbutamol sulfation in the human liver and duodenal mucosa: interindividual variability. Xenobiotica 27, 279-286 (1997).
  • M.A. FERRONI, P.C. GIULIANOTTI, A. PIETRABISSA, F. MOSCA, R. GOMENI, and G.M. PACIFICI: Captopril methylation in human liver and kidney: interindividual variability. Xenobiotica 26, 877-882 (1996).
  • G.M. PACIFICI, M.C. QUILICI, B. GIULIANETTI, R. SPISNI, M. NERVI, L. GIULIANI and R. GOMENI: Ritodrine sulfation in the human liver and duodenal mucosa: interindividual variability. Eur. J Drug Metab. Pharmacokinet. 23, 67-74 (1998).
  • G.M. PACIFICI, A. GUCCI and L. GIULIANI: Testosterone sulfation and glucuronidation in the human liver: interindividual variability. Eur. J. Drug Metab. Pharmacokin. 22, 253-258 (1997).
  • M. CAPPIELLO, L. GIULIANI, A. RANE and G.M. PACIFICI: 5’-Diphosphoglucuronic acid (UDPGA) in the human fetal liver, kidney and placenta. Eur. J. Drug Mratab. and Pharmacokin. 25, 161-164 (2000).
  • G.M. PACIFICI, C. D’ALESSANDRO, A. GUCCI and L. GIULIANI: Sulfation of the heterocyclic amine 1,2,3,4-tetrahydroisoquinoline in the human liver and intestinal mucosa: interindividual variability. Arch. Toxicol. 71, 477-481 (1997).
  • C. De Santi, P.C. Giulianotti, A. Pietrabissa, F. Mosca and G.M. Pacifici: Catechol-O-methyltransferase: interindividual variability and inhibition by entacapone e tolcapone. Eur. J. Clin. Pharmacol. 54, 215-219 (1998).
  • C. De Santi, P. Donatelli, P.C. Giulianotti, A. Pietrabissa, F. Mosca and G.M. Pacifici: Interindividual variability of histamine N-methyltransferase in the human liver and kidney. Xenobiotica. 28, 571-577 (1998).
  • A. BRITTELLI, C. DE SANTI, H. RAUNIO, O, PELKONEN, G. ROSSI and G.M. PACIFICI: Interethnic and interindividual variabilities of platelet sulfotransferases activity in Italians and Finns. Eur. J. Clin. Pharmacol. 55, 691-695 (1999).
  • M.VIETRI, C. DE SANTI, A. PIETRABISSA, F. MOSCA and G.M. PACIFICI: Fenamates and the potent inhibition of human liver phenol sulfotransferase. Xenobiotica 30, 111-116 (2000).
  • M. VIETRI, C. DE SANTI, A. PIETRABISSA, F. MOSCA and G.M. PACIFICI: Inhibition of human liver phenol sulfotransferase by nonsteroidal anti-inflammatory drugs. Eur. J. Clin. Pharmacol. 56, 81-87 (2000).
  • M. VIETRI, A. PIETRABISSA, R. SPISNI, F. MOSCA and G.M. PACIFICI: Differential inhibition of hepatic and duodenal sulfation of (-)-salbutamol and minoxidil by mefenamic acid. Eur. J. Clin. Pharmacol. Ther. 56, 477-479 (2000).
  • C. DE SANTI, A. PIETRABISSA, R. SPISNI, F. MOSCA and G.M. PACIFICI: Sulfation of resveratrol, a natural product present in grapes and wine, in the human liver and duodenum. Xenobiotica 30, 609-617 (2000).
  • C. DE SANTI, A. PIETRABISSA, R. SPISNI, F. MOSCA and G.M. PACIFICI: Sulfation of resveratrol, a natural compound present in wine, is inhibited by natural flavonoids. Xenobiotica. 30, 857-866 (2000).
  • G.M. PACIFICI and A.M. ROSSI: Interindividual variability of sulfotransferases in man. In: “Interindividual Variability in Drug Metabolism in Man” (G.M. Pacifici and O. Pelkonen eds). Pp 434-459 (2001) Taylor & Francis. London. UK. ISBN 0-7484-0864-9.
  • AM. Rossi, M. Bianchi, C. Guarnieri R. Barale GM. Pacifici GM. Genotype-phenotype correlation for thiopurine S-methyltransferase in healthy Italian subjects. Eur J Clin Pharmacol. 57, 51-4 (2001).
  • C. DE SANTI, A. PIETRABISSA, F. MOSCA and G.M. PACIFICI: Glucuronidation of resveratrol, a natural product present in grape and wine, in the human liver. Xenobiotica. 30, 1047-1054 (2000).
  • M. VIETRI, A. PIETRABISSA, F. MOSCA and G.M. PACIFICI: Mycophenolic acid glucuronidation, and inhibition by non-steroidal anti-inflammatory drugs, in human liver and kidney. Eur. J. Clin. Pharmacol. 56, 659-664 (2000).
  • M. Vietri, A. Pietrabissa, F. Mosca, A. Rane, G.M. Pacifici: Human adult and fetal liver sulfotransferases: inhibition by mefenamic acid and salicylic acid. Xenobiotica 31, 153-161 (2001).
  • F. Marchetti, C. De Santi, M. Vietri, A. Pietrabissa, R. Spisni, F. Mosca, G.M. Pacifici: Differential inhibition of human liver and duodenum sulfotransferase activities by quercetin, a flavonoid present in vegetables, fruit and wine. Xenobiotica 31, 841-847 (2001).
  • C. De Santi, A. Pietrabissa, F. Mosca, G.M. Pacifici: Methylation of quercetin and fisetin, flavonoids widely distributed in edible vegetables, fruits and wine, by human liver. Inter. J. Clin. Pharmacol. Ther. 40, 207-212 (2002).
  • M. VIETRI, A. PIETRABISSA, F.MOSCA and G.M. PACIFICI: Inhibition of mycophenolic acid glucuronidation by niflumic acid in human liver: type of inhibition and variability of IC50 of niflumic acid. Eur. J. Clin. Pharmacol. 58, 93-97 (2002).
  • M. VIETRI, R. PIETRABISSA, F. SPISNI, F. MOSCA and G.M. PACIFICI: 7-OH-Flavone is a substrate of human liver and duodenum sulfotransferase whereas 5-OH-flavone and 3-OH-flavone are not sulfated and are potent inhibitors of SULT1A1. Xenobiotica 32, 563-571 (2002).
  • C. DE SANTI, A. PIETRABISSA, F. MOSCA, A. RANE and G.M. PACIFICI: Inhibition of SULT1A1 by quercetin in human adult and fetal livers. Xenobiotica 32, 363-368 (2002).
  • M. VIETRI, F. Vaglini, A. PIETRABISSA, R. SPISNI, F. MOSCA and G.M. PACIFICI: Sulfation of R(-)-apomorphine in human liver and duodenum and inhibition by mefenamic acid, salicylic acid and quercetin. Xenobiotica 32, 587-594 (2002).
  • G. M. PACIFICI: Inhibition of sulfotransferase by drugs and dietary chemicals: a review of the literature. Int. J. Clin. Pharmacol. Ther. 42, 488-495 (2004).
  • M. VIETRI, F. VAGLINI, R. CANTINI and G.M. PACIFICI: Quercetin inhibits the sulfation of R (-) apomorphine in human brain. Int. J. Clin. Pharmacol. Ther. 40, 30-35 (2003).
  • M. VIETRI, A. PIETRABISSA, F. MOSCA, R. SPINSI and G.M.PACIFICI: Curcumin is a potent inhibitor of phenol sulfotransferase (SULT1A1) in human liver and extrahepatic tissues. Xenobiotica 33, 357-363 (2003).
  • A.M. Rossi, V. Maggini, E. Fredianelli, D. DI Bello, A. Pietrabissa, F. Mosca, R. Barale and G.M. Pacifici. Phenotype-genotype relationships of sult1a1 in human liver and variations in the IC50 of the sult1a1 inhibitor quercetin Int. J. Clin. Pharmacol. Ther. 42, 561-567 (2004).
  • G.M. Pacifici: Sulfation of drugs. In: “Human Cytosolic Sulfotransferases” (G.M. Pacifici and M. Cougthrie eds.) Taylor and Francis pp 81, 157-177 (2005).
  • G.M. PACIFICI: Sulfation of drugs and hormones in mid-gestation human fetus. Early Hum Dev 81,- 573-81 (2005).
  • G.M. Pacifici: Transfer of antivirals across the human placenta. Early Human Dev. 81, 647-54 (2005).
  • G.M. PACIFICI: Pharmacokinetics of antivirals in neonate. Early Hum. Dev. (2005)
  • G.M. Pacifici: Placental transfer of antibiotics administered to the mother: a review. Int J. Clinical. Pharmacol. Ther. 44, 57-63 (2006).
  • G.M. PACIFICI: Clinical pharmacokinetics of gentamicin in the neonate: a review of the literature. Curr Topics Pharmacol. 12, 119-127 (2008).
  • G.M. PACIFICI: Peak and trough concentrations of gentamicin in the neonate: a review. Curr. Pediatr. Rev. 5, 2-7 (2009).
  • G.M. PACIFICI: J. Labatia. H. Mulla, I. CHOONARA: Clinical Pharmacokinetics of penicillins in neonates: a review of the literature. Eur. J. Clin. Pharmacol. 65, 191-198 (2009).
  • G.M. PACIFICI: Clinical Pharmacokinetics of aminoglycosides in the neonate. Eur. J. Clin. Pharmacol. 65, 419-427 (2009).
  • PACIFICI G.M.: Pharmacokinetics of cephalosporins in the neonate. A review. Clinics. 66, 1267-1274 (2011).
  • G.M. PACIFICI: Clinical pharmacokinetics of penicillins, cephalosporins and aminoglycosides in the neonate: a review. J Pharmaceuticals. 3, 2568-2591 (2010).
  • G.M. PACIFICI and K. ALLEGAERT: Clinical pharmacokinetics of vancomycin in the neonate: a review. Clinics. 67, 831-7 (2012).
  • GM. PACIFICI: Clinical pharmacology of the loop diuretics furosemide and bumetanide in neonates and infants. Paed. Drugs. 4, 233-46 (2012).
  • G.M. PACIFICI: Clinical pharmacology of indomethacin in preterm infants: implications in patent ductus arteriosus closure. Ped. drugs. 15, 363-376 (2013).
  • G.M. PACIFICI, K. ALLEGAERT: Clinical pharmacology of carbapenem antibiotics in neonates: a review. J Chemother. 26, 67-73 (2014).
  • G.M. PACIFICI: Clinical pharmacology of furosemide in neonates. A review. Pharmaceuticals. 6, 1094-1129 (2013).
  • G. M. PACIFICI: Clinical pharmacology of fentanyl in preterm infants. A review. Ped. Neonatol. 56, 143-148 (2015).
  • G.M. PACIFICI: Clinical pharmacology of midazolam in neonates and children: effect of disease. A Review. Int. J. Pediatr. 2014:309342.
  • G.M. PACIFICI: Differential renal adverse effects of ibuprofen and indomethacin in preterm infants. A review. Clinical Pharmacology: Advances and Applications. Clin Pharmacol. 6, 111-6 (2014).
  • G. M. PACIFICI: Clinical pharmacology of ibuprofen in preterm infants: A meta-analysis of published data. MEDICALEXPRESS. 1, 55-61 (2014).
  • G.M. PACIFICI: Clinical pharmacology of analgesics in infants and the pharmacologic management of pain in neonates. A review. MEDICALEXPRESS. 1, 105-115 (2014).
  • G.M. PACIFICI: Clinical pharmacology of caffeine citrate in preterm infants. MEDICALEXPRESS. 1, 243-250 ( 2014).
  • G.M. PACIFICI: Clinical pharmacology of dobutamine and dopamine in preterm infants. A review. MEDICALEXPRESS 1, 275-283 (2014).
  • G.M. PACIFICI: Clinical pharmacology of ibuprofen and indomethacin in preterm infants with patent ductus arteriosus. Curr Pediatr Rev. 10, 216-237 (2014).
  • G.M. PACIFICI: Treatment of infantile haemangioma with propranolol. A review. MEDICALEXPRESS. 1, 323-327 (2014).
  • G.M. PACIFICI and K. ALLEGAERT: Clinical pharmacology of carbapenems in neonates. J Chemother 26, 67-73 (2014).
  • G.M. PACIFICI and K. ALLEGAERT: Clinical pharmacology of paracetamol in neonates. A review. Cur. Ther. Res. 77, 24-30 (2015).
  • G.M. PACIFICI: Clinical pharmacology of methadone in neonates and in their mothers. Submitted to MEDICALEXPRESS. 2(1):M150103 (2015).
  • G.M. PACIFICI: Clinical pharmacology of theophylline in preterm infants: effects, metabolism and pharmacokinetics. Cur. Pediatr. Rev. 10, 297-303 (2015).
  • G.M. PACIFICI and K. ALLEGAERT: Clinical pharmacology of paracetamol in neonates: a review. Curr. Ther. Res. Clin. Exp. 2014, 77:24-30.
  • G.M. PACIFICI: Effects of surfactants on preterm infant lungs. MEDICALEXPRESS. 2(1):M150206. (2015).
  • G.M. PACIFICI and K. ALLEGAERT: Bronchodilator and anti-hyperkalaemic effects of salbutamol (albuterol) in neonates and young children. J Ped Biochem. 5(3), 82-87 (2015).
  • G.M. PACIFICI: Clinical pharmacology of phenobarbital in neonates: effects, metabolism and pharmacokinetics. Curr. Pediatr. Rev. 12(1), 48-54 (2016).
  • G.M. PACIFICI and K. ALLEGAERT: Clinical pharmacokinetics of amoxicillin in neonates. In Press. J. Chemother. 2015
  • G.M. PACIFICI: Clinical pharmacology of gentamicin in neonates: regimen, toxicology, and pharmacokinetics. MEDICALEXPRESS. 2(5):M150501 (2015).
  • G.M. PACIFICI: Ibuprofen and indomethacin for the closure of the patent ductus arteriosus. MEDICALEXPRESS. 3(3):M160301 (2016).
  • G.M. PACIFICI: Metabolism and pharmacokinetics of morphine in neonates. A review. Clinics. 71(8):474-80 (2016).
  • G.M. PACIFICI: Effects of vitamin D in neonates and young infants. Int. J. Pediatr. 4, 1273-1285 (2016).
  • G.M. PACIFICI: Effects of vitamin A in neonates and young infants. Int. J. Pediatr 4, 1339-1354 (2016).
  • G.M. PACIFICI: Clinical pharmacology of fluconazole in neonates, effects and pharmacokinetics. Int. J. Pediatr. 4, 1475-1489 (2016).
  • G.M. PACIFICI: Effects of vitamin K in neonates and young infants. Int. J. Pediatr. 4, 1611-1624 (2016).
  • G.M. PACIFICI: Effects of vitamin E in neonates and young infants. Int. J. Pdiatr. 4, 1745-1754 (2016).
  • G.M. PACIFICI: Effects of vitamin B12 in neonates and young infants. Int. J. Pdiatr. 4, 1745-1754 (2016).
  • G.M. PACIFICI: Effects of iron in neonates and young infants. Int. J. Pediatr. 1745-1757 (2016).
  • G.M. PACIFICI: Clinical pharmacology of ceftazidime in neonates: effects and Pharmacokinetics. Submitted to Int. J. Pediatr. (2017).
  • G. M. PACIFICI: Clinical pharmacology of teicoplanin in neonates: effects and pharmacokinetics. Int. J. Pediatr. 2016; 4(10): 185-182.
  • G.M. PACIFICI: Clinical pharmacology of meropenem in neonates: effects and pharmacokinetics. Int. J. Pediatr. 2016; 4(11): 395-393.
  • G.M. PACIFICI: The effects and pharmacokinetics of acyclovir in neonates. Int. J. Pediatr. 4(12): 4099-4115 (2016).
  • G.M. PACIFICI: Clinical pharmacokinetics of gentamicin in neonates. Int. J. Pediatr. 5 (4): 4575-4599 (2017).
  • G.M. PACIFICI and G. MARCHINI: Clinical Pharmacology of amikacin in neonates. Int. J. Pediatr. 2 (2): 4407-4428 (2017).
  • G.M. PACIFICI and G. MARCHINI: Clinical pharmacology of cefepime in infants and children. Int. J. Pediatr. 5 (4): 4575-4599 (2017).
  • G.M. PACIFICI and G. MARCHINI: Clinical pharmacology of ceftazidime in neonates: effects and pharmacokinetics. Int. J. Pediatr. 5(5): 4803-4809 (2017).
  • G.M. PACIFICI and G. MARCHINI: Clinical pharmacology of ciprofloxacin in neonates: effects and pharmacokinetics. Int. J. Pediatr. 5(6): 5023-5041 (2017).
  • G.M. PACIFICI and G. MARCHINI: Clinical pharmacology of ceftriaxone in neonates and infants: effects and pharmacokinetics. Int. J. Pediatr. 5(9): 381-341 (2017).
  • G.M. PACIFICI and G. MARCHINI: Clinical pharmacology of cefotaxime in neonates and infants: effects and pharmacokinetics. Int. J. Pediatr. 5(11): 6111-6138 (2017).
  • G.M. PACIFICI: Clinical pharmacology of ampicillin in neonates and infants: effects and pharmacokinetics. Int. J. Pediatr. 2017:5(12):6383-6410.
  • G.M. PACIFICI: Management of typhoid fever bacterial meningitis by chloramphenicol in infants and children. Int. J. Pediatr. 218:6(1):6783-6808.
  • G.M. PACIFICI: Multidrug-resistant in infants and children. Submitted to Int. J. Pediatr. 2018.
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