Education
M.S. Pharmacy, University Medical School of Szeged, Szeged, Hungary, 1979.
Univ.D. Pharmaceutical Chemistry, University Medical School of Szeged, Hungary, 1983.
Thesis: Synthesis of isoquinoline derivatives with potentially pharmacological activities.
Candidate of Sciences Chemistry, Hungarian Academy of Sciences, Budapest, 1994.
Thesis: Investigations on cyclization reactions of 2-arylideneketones to form 1,3-thia and pyrimidine derivatives.
Ph.D. Pharmaceutical Chemistry, University of Szeged, Szeged, Hungary, 1996.
Habilitation Chemistry, University of Pecs, Pecs, Hungary, 2000.
Specialization Certificates:
Preparative chemical laboratory investigations
Medical University of Advanced Studies, Budapest, Hungary, 1985.
Toxicology
Medical University of Advanced Studies, Budapest, Hungary, 1994.
Professional experience
1979-1981 Postgraduate Fellow, Institute of Pharmaceutical Chemistry, University Medical School, Szeged, Hungary.
1981-1993 Assistant Professor, Department of Medical Chemistry, University Medical School, Pecs, Hungary.
1990-1991 (12 months) Fogarty Fellow, Department of Medicinal Chemistry, University of Washington, Seattle, WA, U.S.A.
1993-1999 Senior Lecturer, Department of Medical Chemistry, University Medical School, Pecs, Hungary.
1999-2001 Associate Professor, Department of Medical Chemistry, University Medical School, Pecs, Hungary.
2001 (12 months) Postdoctoral Research Associate, Center for Drug Discovery, University of Florida, Gainesville, FL, U.S.A.
2002-2010 Associate Professor, Head of Institute, Institute of Pharmaceutical Chemistry, University Medical School, Pecs, Hungary.
2003 (3 months) Postdoctoral Research Associate, Department of Medicinal Chemistry, University of Florida, Gainesville, FL, U.S.A.
2009-2015 Head of School of Pharmacy, University of Pecs, Pecs, Hungary.
2010- Professor, Head of Institute, Institute of Pharmaceutical Chemistry, University Medical School, Pecs, Hungary.
2012 (3 months) Senior DAAD Fellow, University of Bonn, Kekulé-Institute of Organic Chemistry and Biochemistry, Bonn, Germany.
2016- Head of Faculty of Pharmacy, University of Pecs, Pecs, Hungary.
Research activities
- Synthesis, synthetic application and structural (UV, IR, NMR) investigation of chalcones and cyclic chalcone analogues (2-benzylidenecyclanones and 2-benzylidenebenzocyclanones) and their ferrocenyl counterparts.
- Structure-activity relationship studies on the effects of chalcones and cyclic chalcone analogues on the cell cycle of cancer cell lines.
- Structure-activity relationship studies on the antioxidant/prooxidant effects of chalcones, estrogens and non-steroidal anti-inflammatory drugs.
- Study on (stereo)chemistry of reaction of alfa,beta-unsaturated carbonyl compounds (chalcones, and cyclic chalcone analogues) with sulphur and nitrogen nucleophilic reagents.
- Investigation of biotransformation of capsaicinoids and non-steroidal anti-inflammatory drugs in the small intestine using ex vivo rat model.
- Chemico-biochemical backgrounds of cancer chemoprevention
Publications
Summary (MTMT.HU)
Number of publications: 104
Number of referred abstracts: 154
Independent citations: 787
Hirsch-index. 19
Selected publications
- Almasi A, Pinto EDLN, Kovacs NP, Fischer T, Markovics Z, Fischer E, Perjesi P
Changes in hepatic metabolic enzyme activities and biliary excretion of 4-nitrophenol in streptozotocin induced diabetic rats
BRAZILIAN JOURNAL OF PHARMACEUTICAL SCIENCES 54:(1) Paper e17347. 9 p. (2018)
- Bernardes A, D’Oliveira GDC, Silezin A, Kuzma M, Molnar S, Noda Perez C, Perjesi P
Reagent-induced asymmetric induction in addition reaction of reduced glutathione onto bis-Mannich chalcones.
ARCHIV DER PHARMAZIE 2018: Paper e1700386. 6 p. (2018)
- Kuzma M, Kovacs N, Sziva L, Maasz G, Avar P, Perjesi P
Oxidation of Hydroxy- and Dihydroxybenzoic Acids Under the Udenfriend’s Conditions. An HPLC Study.
THE OPEN MEDICINAL CHEMISTRY JOURNAL 12: pp. 13-22. (2018)
- Bernardes A, Pérez CN, Mayer M, Da Silva CC, Martins FT, Perjesi P
Study of reactions of two Mannich bases derived of 4′-hydroxychalcones with glutathione by RP-TLC, RP-HPLC and RP-HPLC-ESI-MS analysis
JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY 28:(6) pp. 1048-1062. (2017)
- Rozmer Z, Marton E, Perjesi P
(E)-2-Benzylidenecyclanones: part XIV. Study on interaction of some (E)-2-benzylidenebenzosuberone derivatives with calf thymus DNA by TLC and UV–Vis methods, a DNA cleavage study
MEDICINAL CHEMISTRY RESEARCH 26:(9) pp. 2172-2179. (2017)
- Kuzma M, Nyul E, Mayer M, Fischer E, Perjesi P
HPLC analysis of in vivo intestinal absorption and oxidative metabolism of salicylic acid in the rat.
BIOMEDICAL CHROMATOGRAPHY 30:(12) pp. 2044-2052. (2016)
- Rozmer Zs, Perjesi P
Naturally occurring chalcones and their biological activities
PHYTOCHEMISTRY REVIEWS 15:(1) pp. 87-120. (2016)
- Fischer E, Almasi A, Bojcsev S, Fischer T, Kovacs NP, Perjesi P
Effect of experimental diabetes and insulin replacement on intestinal metabolism and excretion of 4-nitrophenol in rats
CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY 93:(6) pp. 459-464. (2015)
- Huber I, Zupkó I, Kovács JI, Minorics R, Gulyás-Fekete G, Maasz G, Perjesi P
Synthesis and Antiproliferative Activity of Cyclic Arylidene Ketones: Direct Comparison of Monobenzylidene and Dibenzylidene Derivatives
MONATSHEFTE FUR CHEMIE 146:(6) pp. 973-981. (2015)
- Kuzma M, Fodor K, Maasz G, Avar P, Mozsik G, Past T, Fischer E, Perjesi P
A validated HPLC-FLD method for analysis of intestinal absorption and metabolism of capsaicin and dihydrocapsaicin in the rat.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS 103: pp. 59-66. (2015)
- Perjesi P
(E)-2-Benzylidenebenzocyclanones: part XIII-(E)/(Z)-Isomerization of some cyclic chalcone analogues. Effect of ring size on lipophilicity of geometric isomers
MONATSHEFTE FUR CHEMIE 146:(8) pp. 1275-1281. (2015)
