Open Access Peer-reviewed Research Article

Fast diffusion kurtosis imaging for venous stroke caused by cerebral venous thrombosis

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Ipsilateral ADC values
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Submitted   Apr 9, 2024
Published   Sep 23, 2024
Issue    Vol 6 No 1 (2024)
DOI   10.25082/AGPM.2024.01.001

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Haijuan Kang
1. Department of Neurology, Beijing Fengtai Hospital of Integrated Traditional Chinese Medicine and Modern Medicine, Beijing 100072, China; 2. Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing 10053, China
Jiangang Duan
Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing 10053, China
Tao Huang
Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing 10053, China
Chengxu Li
1. Department of Radiology, Xuanwu Hospital, Capital Medical University, Beijing 100053, China; 2. Department of Dermatology, China-Japan Friendship Hospital, Beijing 100029, China
Shaobo Qiu
Department of Neurology, Beijing Fengtai Hospital of Integrated Traditional Chinese Medicine and Modern Medicine, Beijing 100072, China
Sijie Li corresponding author
1. Beijing Key Laboratory of Hypoxic Conditioning Translational Medicine, Xuanwu Hospital, Capital Medical University, Beijing 100053, China; 2. Beijing Institute of Brain Disorders, Collaborative Innovation Center for Brain Disorders, Capital Medical University, Beijing 100069, China; 3. Department of Emergency, Xuanwu Hospital, Capital Medical University, Beijing 100053, China

Abstract

Background: Diffusion kurtosis imaging (DKI) has been found to be more precise than diffusion weighted imaging (DWI) for detecting irreversible infarction in acute ischemic stroke. This study aimed to evaluate whether fast DKI has distinctive advantages in detecting venous stroke caused by cerebral venous thrombosis (CVT).
Methods: All data from patients diagnosed with venous stroke due to CVT and qualified for mechanical recanalization treatment were collected. Fast DKI and DWI were obtained both before and after revascularization therapy, and lesions were measured. Lesion volumes on T2 weighted imaging (T2WI) were followed up at six months.
Results: A total of 11 patients were recruited. Compared to the contralateral brain, ADC values of the lesions in pre-operation increased significantly (1340.12±235.42 vs 919.75±128.98, P < 0.05), while MK decreased (0.59±0.11 vs 0.81±0.12, P < 0.05). And the same changing trend about ADC values (1258.94±185.08 vs 949.81±148.52, P < 0.05) and MK values (0.64±0.12 vs 0.83±0.12, P < 0.05) in post-operation. There was no significant difference in the volume of lesions between DKI and DWI during the same examination period (26.97 vs 29.28, Ppre> 0.05; 13.34 vs 13.14, Ppost> 0.05). However, the lesion volume after revascularization was significantly reduced compared to the first DKI and DWI examinations (26.97 vs 13.34, P < 0.05), and the same as DWI (29.28 vs 13.14, P < 0.05). Volume of T2WI lesions after the 6th month diminished significantly compared with both DKI lesions and DWI lesions before treatment (7.25 vs 26.97, P < 0.05; 7.25 vs 31.19, P < 0.05). Fast DKI had a higher signal to noise ratio (SNR) than traditional DKI and DWI.
Conclusion: The MK of the venous stroke lesions decreased significantly in the subacute stage of CVT, suggesting reversible infarction. Fast DKI has more distinctive superiority in the evaluation of venous stroke. Fast DKI approach may hold great promise for patients in clinical setting because of a higher SNR than DWI. But the sample need to be further expanded because of only 11 patients recruited.

Keywords
diffusion kurtosis imaging, cerebral venous thrombosis, venous stroke

Article Details

Supporting Agencies
This work was financially supported by Beijing Fengtai Hospital of Integrated Traditional Chinese and Western Medicine 2022 Institute Collaborative Innovation Research Fund (YS2022-07).
How to Cite
Kang, H., Duan, J., Huang, T., Li, C., Qiu, S., & Li, S. (2024). Fast diffusion kurtosis imaging for venous stroke caused by cerebral venous thrombosis. Advances in General Practice of Medicine, 6(1), 110-115. https://doi.org/10.25082/AGPM.2024.01.001
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This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

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