Open Access Peer-reviewed Research Article

The preparation of Garcinia Glycosides solid dispersion and intestinal absorption by rat in situ single pass intestinal perfusion

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The infrared spectroscopy of the THS SD and physical mixtures of PEG4000，PEG6000 with THS
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Submitted   Dec 25, 2018
Published   Jan 24, 2019
Issue    Vol 1 No 1 (2019)
DOI   10.25082/JPBR.2019.01.002

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Ye Chen corresponding author
Research Center for Computer Simulating and Information Processing of Biomacromolecules of Liaoning Province; School of Pharmacy, Liaoning University, Shenyang City, Liaoning Province, 110036, China.
Shengnan Li
Research Center for Computer Simulating and Information Processing of Biomacromolecules of Liaoning Province; School of Pharmacy, Liaoning University, Shenyang City, Liaoning Province, 110036, China.
Jingchao Ji
Research Center for Computer Simulating and Information Processing of Biomacromolecules of Liaoning Province; School of Pharmacy, Liaoning University, Shenyang City, Liaoning Province, 110036, China.
Yinghui Chen
Research Center for Computer Simulating and Information Processing of Biomacromolecules of Liaoning Province; School of Pharmacy, Liaoning University, Shenyang City, Liaoning Province, 110036, China.
Ju Liu
Research Center for Computer Simulating and Information Processing of Biomacromolecules of Liaoning Province; School of Pharmacy, Liaoning University, Shenyang City, Liaoning Province, 110036, China.
Yang Wang
Research Center for Computer Simulating and Information Processing of Biomacromolecules of Liaoning Province; School of Pharmacy, Liaoning University, Shenyang City, Liaoning Province, 110036, China.
Hongsheng Liu
School of Life Sciences, Liaoning University, Shenyang City, Liaoning Province, 110036, China.

Abstract

Garcinia Glycosides is a candidate drug obtained by structural modification of Gambogic Acid (GA), which was acquired through High Throughput Screening(HTS). As Garcinia Glycosides is an effective but insoluble anti-tumor drug, the aim of this study was to obtain a solid dispersion form Garcinia Glycosides by using solvent-melt method so that improve the solubility and dissolution rate. The solid dispersion was characterized by High Performance Liquid Chromatography (HPLC), infrared spectroscopy and evaluated the intestinal absorption of the drug by rat in situ single pass intestinal perfusion. The results showed the increase of solubility, dissolution velocity and absorption compared to other forms. This indicated that solid dispersion could greatly improve the relative bioavailability of Garcinia Glycosides in vivo.

Keywords
Garcinia Glycosides, Solid dispersion, Intestinal perfusion, In situ single-pass perfusion method

Article Details

Supporting Agencies
This study was supported by grants from the Drug Discovery Initiative of the National 11th Five Year Plan (2009ZX09103-030) and Innovation Team Project (No: LT2015011) from the Education Department of Liaoning Province. Gareinia glycosides was provided by College of Pharmacy of Liaoning University, New Drug R&D Key Laboratory of Liaoning Province.
How to Cite
Chen, Y., Li, S., Ji, J., Chen, Y., Liu, J., Wang, Y., & Liu, H. (2019). The preparation of Garcinia Glycosides solid dispersion and intestinal absorption by rat in situ single pass intestinal perfusion. Journal of Pharmaceutical and Biopharmaceutical Research, 1(1), 15-20. https://doi.org/10.25082/JPBR.2019.01.002
Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

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