Open Access Peer-reviewed Research Article

Functionalization of carbopol with NVP for designing antibiotic drug loaded hydrogel dressings for better wound management

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FTIR spectra of (a) CP and (b) CP-cl-poly(NVP) polymer
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Submitted   Jan 7, 2019
Published   Jan 22, 2019
Issue    Vol 1 No 1 (2019)
DOI   10.25082/JPBR.2019.01.001

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Baljit Singh corresponding author
Department of Chemistry, Himachal Pradesh University, Shimla -171005, India
Abhishek Dhiman
Department of Chemistry, Himachal Pradesh University, Shimla -171005, India

Abstract

In the present work an attempt has been made to design the antibiotic drug loaded carbopol-poly(NVP) based hydrogel wound dressings for better wound care. The polymer films were characterized by SEM-EDX, AFM, FTIR, 13CNMR, TGA/DTA/DTG, DSC, and swelling studies. Besides drug release, various biomedical properties (viz. blood compatibility, mucoadhesion, oxygen permeability, water vapour transmission rate, microbial penetration, tensile strength, bursting strength, resilience, stress relaxation, and folding endurance) have also been studied. The polymer films have been observed to be biocompatible, permeable to oxygen and water vapour and have absorbed simulated wound fluid 11.37±0.31 g/g of polymer film.The drug release profile followed the Case-II diffusion mechanism and release profile best fitted in Hixson-Crowell's kinetic models.Mechanical properties results showed that the polymer film had 0.65±0.12 Nmm-2 tensile strength, 119.38±14.26% elongationand 25.49±0.72% resilience.

Keywords
Drug delivery, 1-Vinyl-2-pyrollidone, Hydrogel, Wound dressing

Article Details

How to Cite
Singh, B., & Dhiman, A. (2019). Functionalization of carbopol with NVP for designing antibiotic drug loaded hydrogel dressings for better wound management. Journal of Pharmaceutical and Biopharmaceutical Research, 1(1), 1-14. https://doi.org/10.25082/JPBR.2019.01.001
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This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

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