Open Access Peer-reviewed Review

SeDeM Expert System: A review and new perspectives

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SeDeM Diagram
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Submitted   Apr 4, 2019
Published   Apr 24, 2019
Issue    Vol 1 No 1 (2019)
DOI   10.25082/JPBR.2019.01.005

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Huimin Sun corresponding author
National Institutes for Food and Drug Control, Beijing 100050, China
Mingxian Gu
Chongqing University of Science and Technology, Chongqing 401331, China
Tianbing Guan
Chongqing University of Science and Technology, Chongqing 401331, China
Shulin Wan
Chongqing University of Science and Technology, Chongqing 401331, China
Han Zhang
Chongqing University of Science and Technology, Chongqing 401331, China
Xuelian Li
Chongqing University of Science and Technology, Chongqing 401331, China
Songtao Kong
Chongqing University of Science and Technology, Chongqing 401331, China
Jianbing Ren
Chongqing University of Science and Technology, Chongqing 401331, China; Chongqing LIYUN Nozzle Co., Ltd., Chongqing 401332, China
Chuanyun Dai
Chongqing University of Science and Technology, Chongqing 401331, China

Abstract

The SeDeM Expert System was first known as a galenic pre-formulation system, which was based on the experimental research and quantitative determination of powdered substances. And the mathematical formula provided by the SeDeM Expert System has plays an important role in the study of powder properties. The system can be used not only to evaluate the powder direct compression (DC) of excipients and active pharmaceutical ingredients (API's), but also to predict the possible formulations, so it can reduce unnecessary research and trials, and shorten the time of development. In this paper, the research development and application of SeDeM Expert System in DC was summarized, and the results showed that with a few exceptions, the system was skilled in predicting acceptable tablet formulations. Finally, the new application prospect of the system is presented, including the application of the Internet traffic and content management (iTCM) database and the new co-processed excipients.

Keywords
SeDeM Expert System, radar graph, powder, direct compression, pre-formulation, co-processed

Article Details

How to Cite
Sun, H., Gu, M., Guan, T., Wan, S., Zhang, H., Li, X., Kong, S., Ren, J., & Dai, C. (2019). SeDeM Expert System: A review and new perspectives. Journal of Pharmaceutical and Biopharmaceutical Research, 1(1), 36-47. https://doi.org/10.25082/JPBR.2019.01.005
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This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

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