Open Access Peer-reviewed Case Report

Optimal management and the role of radiotherapy in the complex treatment of primary mediastinal seminoma: A clinical case with literature review

Article Sidebar

Thorax CT before chemotherapy and radiotherapy
Download PDF
Submitted   Jan 4, 2020
Published   Mar 6, 2020
Issue    Vol 1 (2019)
DOI   10.25082/CCR.2019.01.005

Views

2982

Downloads

1508

Citations

PlumX Metrics

Main Article Content

Lena Marinova corresponding author
Department of radiotherapy, Oncology Centre, Russe, Bulgaria
Rositsa Krasteva
Clinic of Radiotherapy and Oncology, Uni Hospital, Panagyurishte, Bulgaria
Zahari Zahariev
Clinic of Radiotherapy and Oncology, Uni Hospital, Panagyurishte, Bulgaria

Abstract

The Primary Mediastinal Seminoma (PMS) is a rare extragonadal malignant germ-cell tumor. We report a clinical case of our practice, which is the reason for this literature review and try to find the optimal multimodal therapeutic option and the role of radiotherapy.

Keywords
seminoma, mediastinum, complex treatment, radiotherapy

Article Details

How to Cite
Marinova, L., Krasteva, R., & Zahariev, Z. (2020). Optimal management and the role of radiotherapy in the complex treatment of primary mediastinal seminoma: A clinical case with literature review. Current Cancer Reports, 1(1), 24-27. https://doi.org/10.25082/CCR.2019.01.005
Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

References

  1. Friedman NB. Germinoma of the pineal: its identity with germinoma (seminoma) of the testes. Cancer Research, 1947, 7(6): 363- 368. https://cancerres.aacrjournals.org/content/canres/7/6/363.full.pdf
  2. Abell MR, Fayos JV and Lampe L. Retroperitoneal germinomas (seminomas) without evidence of testicular involvement. Cancer, 1965, 18(3): 273-290. https://doi.org/10.1002/1097-0142(196503)18:3h273::AID-CNCR2820180304i3.0.CO;2-3
  3. Nathan B and Friedman MD. The comparative morphogenesis of extragenital and gonadal teratoid tumors. Cancer, 1951, 4(2): 265- 276. https://doi.org/10.1002/1097-0142(195103)4:2h265::AID-CNCR2820040211i3.0.CO;2-X
  4. Polansky SM, Barwick KW and Revie CE. Primary mediastinal seminoma. American Journal of Roentgenology, 1979, 132(1): 17- 21. https://doi.org/10.2214/ajr.132.1.17
  5. Fang FM, Ko SF, Hwang CH, et al. Healing of superior vena cava defect in mediastinal seminoma with invasion. The Annals of Thoracic Surgery, 2000, 70(2): 667-669. https://doi.org/10.1016/S0003-4975(00)01373-4
  6. Hainsworth J. Diagnosis, staging, and clinical characteristics of the patient with mediastinal germ cell carcinoma. Chest Surgery Clinics of North America, 2002, 12(4): 665-672. https://doi.org/10.1016/S1052-3359(02)00031-5
  7. Kitami A, Suzuki T, Suzuki S, et al. Primary Seminoma in the Middle Mediastinum: Case Report in a 69-year-old Male. Japanese Journal of Clinical Oncology, 1998, 28(2): 142-144. https://doi.org/10.1093/jjco/28.2.142
  8. Saraiva LR, Brindeiro F, Saraiva TB, et al. Cardiac extension of primary mediastinal seminoma compressing the right ventricular outflow tract. Arquivos brasileiros de cardiologia, 2001, 76(2): 152-154. https://doi.org/10.1590/S0066-782X2001000200006
  9. Strollo DC, Rosado-de-Christenson ML, Jett JR, et al. Primary mediastinal tumors: Part 1. Tumors of the anterior mediastinum. Chest, 1997, 112(2): 511-522. https://doi.org/10.1378/chest.112.2.511
  10. Oyoshi T, Nakayama M, Hirano H, et al. Intracranial dural metastasis of mediastinal seminoma. Neurologia medico-chirurgica, 2000, 40(8): 423-426. https://doi.org/10.2176/nmc.40.423
  11. Hosono M, Machida K, Honda N, et al. Intense Ga-67 accumulation in pure primary mediastinal seminomas. Clinical Nuclear Medicine, 2003, 28(1): 25-28. https://doi.org/10.1097/00003072-200301000-00006
  12. Luna M and Valenzuela-Tamariz J. Germ cell tumors of the mediastinum, postmortem findings. American Journal of Clinical Pathology, 1976, 65(4): 450-454. https://doi.org/10.1093/ajcp/65.4.450
  13. Cox JD. Primary malignant germinal tumors of the mediastinum. Cancer, 1975, 36(3): 1162-1168. https://doi.org/10.1002/1097-0142(197509)36:3h1162::AID-CNCR2820360351i3.0.CO;2-0
  14. Jain KK, Bosl GJ, Bains MS, et al. The treatment of extragonadal seminoma. Journal of Clinical Oncology, 1984, 2(7): 820-827. https://doi.org/10.1200/JCO.1984.2.7.820
  15. Takeda S, Miyoshi S, Ohta M, et al. Primary germ cell tumors in the mediastinum. A 50-year experience at a single Japanese institution. Cancer, 2003, 97(2): 367-376. https://doi.org/10.1002/cncr.11068
  16. Shepherd FA, Ginsberg R, Patterson GA, et al. Is there ever a role for salvage operations in limited small-cell lung cancer? The Journal of Thoracic and Cardiovascular Surgery, 1991, 101(2): 196-200. https://doi.org/10.1016/S0022-5223(19)36752-2
  17. Motzer R, Bosl G, Heelan R, et al. Residual mass: an indication for further therapy in patients with advanced seminoma following systemic chemotherapy. Journal of Clinical Oncology, 1987, 5(7): 1064-1070. https://doi.org/10.1200/JCO.1987.5.7.1064
  18. Bush SE, Martinez A and Bagshaw MA. Primary mediastinal seminoma. Cancer, 1981, 48(8): 1877-1882. https://doi.org/10.1002/1097-0142(19811015)48:8h1877::AID-CNCR2820480827i3.0.CO;2-B
  19. Bukowski RM, Wolf M, Kulander BG, et al. Alternating combination chemotherapy in patients with extragonadal germ cell tumors: a Southwest Oncology Group study. Cancer, 1993, 71(8): 2631-2638. https://doi.org/10.1002/1097-0142(19930415)71:8h2631::AID-CNCR2820710831i3.0.CO;2-G
  20. Uematsu M, Kondo M, Dokiya T, et al. The role of radiotherapy in the treatment of primary mediastinal seminoma. Radiotherapy and Oncology, 1992, 24(4): 226-230. https://doi.org/10.1016/0167-8140(92)90228-M
  21. Gerl A, Clemm C, Lamerz R, et al. Cisplatin-based chemotherapy of primary extragonadal germ cell tumors. A single institution experience. Cancer, 1996, 77(3): 526-532. https://doi.org/10.1002/(SICI)1097-0142(19960201)77:3h526::AID-CNCR15i3.0.CO;2-6
  22. Pectasides D, Aravantinos G, Visvikis A, et al. Platinum-based chemotherapy of primary extragonadal germ cell tumours: the Hellenic Cooperative Oncology Group experience. Oncology, 1999, 57(1): 1-9. https://doi.org/10.1159/000011993
  23. Einhorn LH and Donohue J. Cis-diaminedichloroplatinum, vinblastine, and bleomycin combination chemotherapy in disseminated testicular cancer. Annals of Internal Medicine, 1977, 87(3): 293-298. https://doi.org/10.7326/0003-4819-87-3-293
  24. Giaccone G. Multimodality treatment of malignant germ cell tumours of the mediastinum. European Journal of Cancer and Clinical Oncology, 1991, 27(3): 273-277. https://doi.org/10.1016/0277-5379(91)90514-E
  25. Childs WJ, Goldstraw P, Nichols JE, et al. Primary malignant mediastinal germ cell tumors: improved prognosis with platinumbased chemotherapy and surgery. British Journal of Cancer, 1993, 67: 1098-1101. https://doi.org/10.1038/bjc.1993.201
  26. Motzer RJ, Mazumdar M, Gulati SC, et al. Phase II trial of high-dose carboplatin and etoposide with autologous bone marrow transplantation in first-line therapy for patients with poor-risk germ cell tumors. Journal of the National Cancer Institute, 1993, 85(22): 1828-1835. https://doi.org/10.1093/jnci/85.22.1828
  27. Flechon A, Biron P, Philip I, et al. High dose chemotherapy with autologous stem cell support in the treatment of germ cell tumors: experience of the centre Leon-Berard between 1982 and 1996. Bull Cancer, 1999, 86(4): 391-399. https://www.ncbi.nlm.nih.gov/pubmed/10341344
  28. Bush SE, Martinez A and Bagshaw MA. Primary mediastinal seminoma. Cancer, 1981, 48(8): 1877-1882. https://doi.org/10.1002/1097-0142(19811015)48:8h1877::AID-CNCR2820480827i3.0.CO;2-B
  29. Xu X, Sun C, Zhang L, et al. A case of mediastinal seminoma presenting as superior vena cava syndrome. Internal Medicine. 2012, 51(10): 1269-1272. https://doi.org/10.2169/internalmedicine.51.7274
  30. Giaccone G. Multimodality treatment of malignant germ cell tumours of the mediastinum. European Journal of Cancer and Clinical Oncology, 1991, 27(3): 273-277. https://doi.org/10.1016/0277-5379(91)90514-E
  31. Fatimi SH, Shahid B, Hanif HM, et al. Mediastinal seminoma presenting as superior vena cava syndrome and tracheal obstruction. Journal of the Pakistan Medical Association, 2010, 60(10): 861-862.
  32. Liu TZ, Zhang DS, Liang Y, et al. Treatment strategies and prognostic factors of patients with primary germ cell tumors in the mediastinum. Journal of Cancer Research and Clinical Oncology volume, 2011, 137: 1607-1612. https://doi.org/10.1007/s00432-011-1028-7