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(E)-2-Benzylidenecyclanones: Part XVI.† Study on the interaction of some (E)-2-benzylidenebenzosuberone derivatives with serum albumin by UV-Vis method, inhibitory effect on topoisomerase

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UV-Vis absorption spectra of HSA
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Submitted   Jul 13, 2020
Published   Aug 14, 2020
Issue    Vol 2 No 1 (2020)
DOI   10.25082/JPBR.2020.01.003

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Zsuzsanna Rozmer corresponding author
Department of Pharmaceutical Chemistry, University of Pécs, Rókus Str. 2, Pécs 7624, Hungary
Pál Perjési
Department of Pharmaceutical Chemistry, University of Pécs, Rókus Str. 2, Pécs 7624, Hungary

Abstract

Interaction of some cyclic chalcone analogs, (E)-2-(4-X-benzylidene)-1-benzosuberone derivatives with bovine serum albumin (BSA) and human serum albumin (HSA) has been investigated using UV-Vis spectroscopic methods. Recording the UV-Vis spectra of compounds in the presence of BSA or HSA indicated interaction of the molecules with the hydrophobic binding site(s) of the proteins. Investigated analogs have shown remarkable topo I and topo II inhibitory activity compared to camptothecin and etoposide, respectively, at 40 μM concentration. The observed interactions between the cyclic chalcone analogs and the cellular macromolecules might play a role in the previously detected cytotoxicity against several tumor cell lines.

Keywords
cyclic chalcone analogs, enones, bovine serum albumin, human serum albumin, UV-Vis spectroscopy, DNA topoisomerases I and II

Article Details

How to Cite
Rozmer, Z., & Perjési, P. (2020). (E)-2-Benzylidenecyclanones: Part XVI.† Study on the interaction of some (E)-2-benzylidenebenzosuberone derivatives with serum albumin by UV-Vis method, inhibitory effect on topoisomerase. Journal of Pharmaceutical and Biopharmaceutical Research, 2(1), 118-125. https://doi.org/10.25082/JPBR.2020.01.003
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