Open Access Peer-reviewed Research Article

Tandem reaction for the synthesis of bicyclic ortho-aminocarbonitrile derivatives using DMAPA as a cheap and efficient catalyst

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Submitted   Oct 17, 2020
Published   Dec 3, 2020
Issue    Vol 2 No 2 (2020)
DOI   10.25082/JPBR.2020.02.001

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Lisha Wu
Weihai Ocean Vocational College, Weihai 264300, China
Shiqiang Yan corresponding author
Shandong Dyne Marine Biopharmaceutical Co., Ltd., Weihai 264300, China & College of Chemistry and Molecular Engineering, Qingdao University of Science and Technology, Qingdao 266042, China
Yinta Li
Weihai Ocean Vocational College, Weihai 264300, China

Abstract

To develop a new method for the synthesis of bicyclic ortho-aminocarbonitrile derivatives. Reaction of aromatic aldehydes, cycloketones and malononitrile with catalytic amount of 3-(dimethylamino)- 1-propylamine (DMAPA) in ethanol via Knoevenagel-Michael cascades. The bicyclic ortho-aminocarbonitrile derivatives were obtained with good to excellent yields along with short reaction times. The universality, excellent yields, mild reaction and easy collection through simple filtration indicate the preparation of orthoaminocarbonitriles derivatives is an efficient and suitable protocol, which use one-pot multicomponent reaction of aromatic aldehyde, cycloketone, and 2 equiv. of malononitrile under the catalytic amount of DMAPA in ethanol.

Keywords
ortho-Aminocarbonitriles, DMAPA, tandem reaction, one-pot

Article Details

How to Cite
Wu, L., Yan, S., & Li, Y. (2020). Tandem reaction for the synthesis of bicyclic ortho-aminocarbonitrile derivatives using DMAPA as a cheap and efficient catalyst. Journal of Pharmaceutical and Biopharmaceutical Research, 2(2), 145-152. https://doi.org/10.25082/JPBR.2020.02.001
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This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

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