Open Access Peer-reviewed Research Article

Thyroid dysfunction in Congolese subjects with Down syndrome

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Functional and Morphological findings in Congolese Down syndrome patients
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Submitted   Jul 3, 2020
Published   Aug 10, 2020
Issue    Vol 2 (2020)
DOI   10.25082/TCPP.2020.01.004

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Toni Kasole Lubala
Department of Pediatrics, University of Lubumbashi, Lubumbashi, Democratic Republic of Congo
Olivier Mukuku corresponding author
Institut Supérieur des Techniques Médicales de Lubumbashi, Lubumbashi, Democratic Republic of Congo
Tony Kayembe-Kitenge
Laboratory of Clinical Toxicology, School of Public Health, University of Lubumbashi, Lubumbashi, Democratic Republic of Congo
Prosper Muenze Kayamba Kalenga
Department of Gynecology and Obstetrics, University of Lubumbashi, Lubumbashi, Democratic Republic of Congo
Prosper Lukusa Thilobo
Department of Pediatrics, Centre for Human Genetics, University of Kinshasa, Kinshasa, Democratic Republic of Congo
Oscar Numbi Luboya
Department of Pediatrics, University of Lubumbashi, Lubumbashi, Democratic Republic of Congo & Institut Supérieur des Techniques Médicales de Lubumbashi, Lubumbashi, Democratic Republic of Congo
Jean Vanderpas
Medical Microbiology Laboratory, Communicable and Infectious Diseases, Scientific Institute of Public Health, Brussels, Belgium

Abstract

Objective: The present study aims to assess the proportion and the pattern of thyroid dysfunction in a population of Congolese subjects with Down Syndrome.
Methods: A total of 34 subjects with Down syndrome were recruited from Lubumbashi (Democratic Republic of Congo). Thyroid morphology was assessed by sonography. Serum T3, T4, FT4, TSH, Thyroglobulin, Thyroid peroxidase antibody (TPOAb) and antithyroglobulin antibody (TgAb) were measured.
Results: The mean age of the patients was 13 years (range: 3 and 47 years). Of 34 Down syndrome subjects, 6 cases (17.6%) were found to have subclinical hypothyroidism. No patient had hyperthyroidism. Among 29 subjects with a thyroid ultrasound imaging, 25 patients (86.2%) were found to have morphological abnormalities of the gland. Regarding thyroid autoantibodies, TPOAb was positive in 1 case (2.9%) and TgAb was positive in 1 case (2.9%).
Conclusion: The results were compared between patients with hypothyroidism and with normal thyroid function. There was no statistical difference in terms of age, sex, nutritional status, antibody levels and thyroid volume between these two groups. Conclusions: In our series, the proportion of hypothyroidism is relatively important but it remains largely under the prevalence reported in international studies.

Keywords
subclinical hypothyroidism, autoimmunity, Down syndrome, Congo

Article Details

How to Cite
Lubala, T., Mukuku, O., Kayembe-Kitenge, T., Kalenga, P., Thilobo, P., Luboya, O., & Vanderpas, J. (2020). Thyroid dysfunction in Congolese subjects with Down syndrome. Theory and Clinical Practice in Pediatrics, 2(1), 38-43. https://doi.org/10.25082/TCPP.2020.01.004
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This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

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