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Targeted molecular therapy (modified RIST regimen) in relapsed high risk stage IV neuroblastoma: two cases report

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Submitted   Dec 29, 2017
Published   Jan 2, 2018
Issue    Vol 2 (2020)
DOI   10.25082/TCPP.2018.01.002

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Paolo Indolfi, MD corresponding author
Unit of Pediatric Oncology, Pediatric Department, Second University of Naples, via Luigi De Crecchio 2 80138 Naples, Italy
Selim Corbacioglu, MD
Department of Pediatrics and Adolescent Medicine, University of Regensburg, Regensburg, Germany
Silverio Perrotta, MD
Unit of Pediatric Oncology, Department of Women-Children and General and Specialistic Surgery, University of Campania “ Luigi Vanvitelli”, Naples, Italy
Francesca Rossi, MD
Unit of Pediatric Oncology, Department of Women-Children and General and Specialistic Surgery, University of Campania “ Luigi Vanvitelli”, Naples, Italy
Antonio Marte, MD
Department of Pediatric Surgery, University of Campania “ Luigi Vanvitelli”, Naples, Italy
Elvira Pota, MD
Unit of Pediatric Oncology,Department of Women-Children and General and Specialistic Surgery, University of Campania “ Luigi Vanvitelli”, Naples, Italy
Martina Di Martino, MD
Unit of Pediatric Oncology,Department of Women-Children and General and Specialistic Surgery, University of Campania “ Luigi Vanvitelli”, Naples, Italy
Daniela Di Pinto, MD
Unit of Pediatric Oncology,Department of Women-Children and General and Specialistic Surgery, University of Campania “ Luigi Vanvitelli”, Naples, Italy
Cristiana Indolfi, MD
Unit of Pediatric Oncology,Department of Women-Children and General and Specialistic Surgery, University of Campania “ Luigi Vanvitelli”, Naples, Italy
Fiorina Casale, MD
Unit of Pediatric Oncology,Department of Women-Children and General and Specialistic Surgery, University of Campania “ Luigi Vanvitelli”, Naples, Italy

Abstract

The prognosis for children with recurrent or refractory neuroblastoma remains a significant clinical challenge, and currently there are no known curative salvage regimens. In this paper we investigated the effect of imatinib with rapamycin and the chemotherapeutic agents temozolomide and irinotecan. We treated two children with recurrent neuroblastoma with this so called RIST protocol. Both patients, off therapy for 15 and 31 months, respectively are well, and developing normally, without any complications. These findings suggest that a combination regimen of RIST may provide a therapeutic benefit with a favorable toxicity profile to a unfortunate subset of patients with neuroblastoma.

Keywords
RIST therapy, neuroblastoma, pediatric cancer

Article Details

How to Cite
Indolfi, P., Corbacioglu, S., Perrotta, S., Rossi, F., Marte, A., Pota, E., Martino, M., Pinto, D., Indolfi, C., & Casale, F. (2018). Targeted molecular therapy (modified RIST regimen) in relapsed high risk stage IV neuroblastoma: two cases report. Theory and Clinical Practice in Pediatrics, 2(1), 29-31. https://doi.org/10.25082/TCPP.2018.01.002
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This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

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